While I'm a big fan of the White Stripes in general, and that song specifically, I'm strongly opposed to playing it in the Big House. Is everyone else aware of just how often they play that at the Horseshoe, and how all of the Buckeye fans make a little "O" symbol with their hands? I believe they stole that from Oregon, maybe? They definitely didn't come up with it on their own, as usual, but they do it. As do countless other schools.
When we're rawk-ing out to something that has been appropriated by our biggest rivals, who have been doing it for at least a year or two (if not longer), I think it makes us look foolish.
I know it won't be a popular opinion around here, but I prefer "In the Big House" being played if only because it is unique to us. I'm in full agreement with the poster above who said that they'd prefer it came from an anonymous source rather than Nickelback's mascara-loving guitar techs, but at least I don't cringe and have "O-H.... I-O" flashbacks every time I hear it.