OT: Promising development with antivirals and covid-19
Very promising research being done at University of Florida. They are studying three antivirals, two which they believe have promising effects on their ability to combat the progression of the virus. One being Remdesivir, the other little less known any viral called Galidesivir. I have done some research on Galidesivir, and it is being funded by the government, with studies in Brazil as well as the University of wisconsin.While we all hope for a vaccine that will be effective, I think antivirals will be what really helps in the long run. Very similar to the HIV pandemic where antivirals have become the forefront in fighting the disease.
https://m.ufhealth.org/news/2020/trio-medications-showing-early-promise-against-coronavirus-uf-health-researchers-find
September 9th, 2020 at 11:50 AM ^
Are there any other Desivirs being tested? It seems like testing just two Desivirs is putting all your eggs in a two Desivir basket!
September 9th, 2020 at 1:15 PM ^
Let’s hope the desivirs are the Glasgows of the antiviral families. We can get all of them and everyone benefits!
September 9th, 2020 at 12:07 PM ^
Yikes, largely in vitro analysis here. This article could well have been from march, given what they talk about.
If anyone wants a good meta analysis from BMJ with a solid infographic to get a better grasp on where we are clinically in treating the virus, check this out
https://www.bmj.com/content/370/bmj.m2980
September 10th, 2020 at 11:40 AM ^
THANK YOU for this post! I was just thinking to myself "I wish I could find a good meta analysis from BMJ with a solid infographic, maybe I'll check out MGOBLOG, which at one time used to be about Michigan sports," and guess what? This website DID NOT DISAPPOINT! Now I am all jazzed up to check out this tasty link you provided!
September 9th, 2020 at 12:29 PM ^
the bradykinin hypothesis which took the Oak Ridge supercomputer 1 week of processing data from 40,000 genes from 17,000 genetic samples is very interesting. it explains the jello lung problems as well as other systemic effects of the disease, neuro, cardio, GI. hopefully more effective treatments can be developed.
https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63
September 9th, 2020 at 12:50 PM ^
That's very interesting, thanks for posting. In the spring we were still slowing coming around to the idea that it's vascular rather than respiratory. This takes that even further, and this level of understanding makes it seem like we'll get some more effective treatments in the near future.
September 9th, 2020 at 2:00 PM ^
Thanks for link, hadn't seen that yet. Seemingly very plausible mechanism if action this virus "performs"!
September 9th, 2020 at 3:03 PM ^
Damn why didn't I think of that?
That's crazy shit tho, change the expression of one receptor and all hell can break loose.
September 9th, 2020 at 12:45 PM ^
There is a lot of hope for galidesivir..... much less toxic than remdesivir and there is anticipation that an emergency use authorization is coming soon based upon primate studies, followed by an approval later in the year from the trial in Brazil. The ultimate hope is that it works and that they can make version taken orally
September 9th, 2020 at 2:47 PM ^
As a beneficial side effect, Giladesivir gives you toned abs.
September 9th, 2020 at 11:05 PM ^
Lol. Totally forgot the days when ESPN’s morning programming on its single channel was a string of workout shows.
Bring back Kiana!!
September 9th, 2020 at 1:16 PM ^
I peaked in high school.
September 9th, 2020 at 1:18 PM ^
No argument here.
September 9th, 2020 at 2:01 PM ^
Through holes into the lockerrooms?!
September 9th, 2020 at 4:45 PM ^
I was somewhat popular if by popular I mean like 15% popular back in HS.
September 9th, 2020 at 1:23 PM ^
Another company working on antibody treatments is Centivax - they had great results in treating hamsters but it’s a smaller company so won’t be available for human use until next year. They were featured in the Pandemic documentary on Netflix.
September 9th, 2020 at 1:48 PM ^
Missed the boat on not calling either of them Gatordesivir.
September 9th, 2020 at 2:41 PM ^
They already have Gatorade, no need to get greedy.
September 9th, 2020 at 4:38 PM ^
ZAT'S ZE JOKE
September 9th, 2020 at 4:38 PM ^
ZAT'S ZE JOKE
September 9th, 2020 at 2:40 PM ^
Is this the same outfit that invented gatorade?
September 9th, 2020 at 4:13 PM ^
Interesting article on Gilead's earlier "version" of remdesivir and whether it would have been better to pursue this (soon to be off patent?) drug...
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The OP's post is a bit of an odd article, unless I'm misreading it (possible), as there are clin trials underway for favi and galidesivir that will give the answer more definitively than what the UF labs in the article seem to be doing.
September 9th, 2020 at 4:32 PM ^
I know personally folks whose lives may have been saved by Remdisivir (plus early intervention and plasma).
September 9th, 2020 at 6:46 PM ^
I wrote it before, and may write it again: scientists must be going loopy, shifting from a lifetime career of anonymity in their patient work to having their every move & word & gesture dissected as if it were a football game.