University of Michigan scientists find brain cancer breakthrough
Here’s some good cancer news! A potentially big breakthrough for the fight against brain cancer, from researchers at our favorite university. Didn’t see this posted, but if it was, I think this is positive enough for a repost.
Go Blue!
Summary (from link):
- Scientists have fabricated a nanoparticle to deliver an inhibitor to brain tumor in mouse models, where the drug successfully turned on the immune system to eliminate the cancer. The process also triggered immune memory so that a reintroduced tumor was eliminated--a sign that this potential new approach could not only treat brain tumors but prevent or delay recurrences.
https://www.sciencedaily.com/releases/2022/05/220526095557.htm
Awesome, hopefully clinical trials are on the way soon - Leaders & Best. Fuck Cancer!!!
Gene editing has advanced to the point where non-human organ transplants are also close to starting larger scale human trials.
Bless all these researchers and medical personnel.
Science nowadays is Science non-fiction.
Very cool. Looks promising. Thanks for posting.
Wow - this is the best news I have heard in a long time! This really makes me proud to be an alum, fan and general supporter of our (mostly) beloved University.
Now THAT is a great first step! Kudos to the team of researchers.
Great news. Hope it helps cure dipg in children.
That would indeed be awesome. Anything that could help with that would be amazing, even incremental progress. I give a lot of folks bad news about cancer but "I'm sorry, it looks as though your child has DIPG" is as bad as it gets.
i just googled it and it turned my stomach to a pit. sigh. some awful things in this world... some natural.. some man made..
Lloyd Carr's grandson, Chad, died of DIPG at 4 yrs old. It was a publicly horrible thing Lloyd's son and DIL went through. It is why Chase Winovich is always (and still) fundraising for ChadTough. It's a charity to raise funds for DIPG research.
I usually just lurk here, but I thought I'd chime in on this. I'm an adult who has had to come to terms with being diagnosed with terminal brain cancer and with an understanding of how difficult that is, Chad's story is just so unfair and it makes me sick to think about. Shortly before he passed, there was a campaign over here that I latched on to and still donate/try to spread the word about.
I am sorry to hear of your diagnosis and appreciate you sharing that difficult information. With research like this going on across the world, there is always a chance a treatment or cure can be found. Take care.
You have a lot to teach us, seeing the world from your perspective. (that came across as weirdly sarcastic, but I mean it sincerely, your "come to terms" is a level of maturity that many of us never get to, v easy to deny our mortality).
In the pregame intro video, wouldn't it be a dream-of-a-lifetime if James Earl Jones aka Lord Vader said, "We are the best university in the world. We cured brain cancer!"
This article gives me a new hope.
He can already say polio.
That's great news. My cousin had glioblastoma and he has survived so far without regression thanks to other innovative treatments (that seem somewhat similar to this). It's the most difficult cancer to treat and it is especially tricky because the recurrence rates are so high. GO BLUE!!!
Phenomenal and encouraging news!
Leaders and Best... INDEED!
I work with stuff like this all the time.
It's super cool but man there's 4-6 years of work (or more now with the preclinical and clinical backlogs, we're booking studies 1-2 years out) before this even gets to Phase 1.
I wonder if my company will get to do all the preclinical work. Probably. We handle like 85% of all FDA approved drugs from early discovery research up through IND/BLA
Everytime I see these, I think: this is the easy part and I wonder how many novel excipients. are going into this that are going to need to pass GLP TOX to get into first in human. The good news is that it's cancer so that makes things a little easier from a Reg standpoint. A much larger issue is probably getting the proteins for the NP made in large enough quantity for phase 1. All the good CMOs have major backlogs from growth media shortages and general demand.
Hell yeah. Fuck Cancer
My mother in law is a stage 4 breast cancer patient for 3 years now. UM has done an amazing job ridding her body of the fucking disease, but that brain/body barrier is a whole new ballgame.
I pray that she can be part of any/all clinical trials for this!
Hail
Great news!1 I have stage 3 brain cancer currently and am currently doing chemo and radiation can disable but it is not cureable at the moment. I know they are close to a cure from what doctors are telling me, so it is promising.
Oh my gosh, wishing you all the best. 🙏🏽🙏🏽🙏🏽
Yes, we ARE curing cancer
This is great news. A cousin of mine recently died from brain cancer after several years of experimental treatment at OSU's cancer institute. He suffered greatly and his family is grief stricken about the whole ordeal. May the Lord bless scientists anywhere who can make a breakthrough against this horrific illness.
Fantastic news!
This so cool! Amazing how the immune system works. Fantastic that they found a way the kick start the system.
For real. If you really want to blow your mind, look up CAR T-cells, that therapy is curing people right now. The gist of it being that a patient’s own white blood cells are collected. Then they get “trained” to target a protein that’s only on the cancer cells (usually for leukemia, but lots of work being done in other cancers). Those same cells then get infused back into the same patient. Because of their “training”, those cells attack cancer cells as though they were attacking an infection.
My oncologist recently told me about this treatment (I have leukemia in remission) and how UM is in the forefront in the research. Kudos to all the medical staff who do such precious work.
I lost a sister and my mom to cancer, though neither were brain cancers. Nonetheless...
FUCK CANCER
That is all.
Mice are lucky there are so many scientists working hard to cure their brain cancer.
This seems like it could be great news in the fight against other cancers too!
Science, bitches
I lost both my father and my grandmother to brain cancer, so I have a special loathing for that particular disease. This news brightens my day immensely.
hail to the victors! seriously good news in a chaotic time
Its going to be a red letter date in human history when we find a way to conquer cancer and Alzheimers.
Such great news to see!
Qwerty