Everyone Murders

August 7th, 2017 at 4:46 PM ^

Not a fan of OSU or their fans, but this is pretty damned cool.  Every once in a while the Buckeyes will produce a medical advance, a Jesse Owens or a Jack Nicklaus that I not only can't hate, but actually admire a lot.

Good for you, Buckeyes.  I hope this is a gateway to lights-out medical advances.

mGrowOld

August 7th, 2017 at 4:54 PM ^

I have a very rare form of cancer and the preminent center for research and treatment in the US (and some would argue the world) is the Davis Cancer center at OSU.  I've been there many times and have always been treated amazingly and as I write this I am 8 years cancer-free and even though the cells are in my lymph nodes they are remaining dormant and god & Davis cancer center willing-I'll die with the desease, not from it.

Some things are bigger than football guys.  This one is for me.

Everyone Murders

August 7th, 2017 at 5:11 PM ^

You had referenced elsewhere that you had a bout with cancer and were cancer-free, but I did not realize that you faced the spectre of latent cancer cells in your lymph nodes.  As you say, some things are bigger than football, and all the best to you as your treatment/monitoring progresses.

I mean, we'll all still bust your balls periodically (the Browns? - really??), but I'm confident the board at large is glad to hear you've got good treatment options at Davis and things are going well.  Good luck with this moving forward!

Goggles Paisano

August 8th, 2017 at 6:10 AM ^

I would kindly disagree and baking soda/water is not electronically charged ionized water.  I am no expert in this field but I have heard several first hand accounts of people that are now cancer free and they believe it to be from changing their water to alkaline.  It was proven that cancer cannot thrive in an alkaline environment so intuitively it makes sense.  

Noah

August 8th, 2017 at 8:51 AM ^

Your last sentence may be correct - although I haven't seen research on that - but it's irrelevant. It is impossible to "alkalinize" your body by drinking water with baking soda or alkaline minerals or whatever. Your body constantly corrects its own pH because you can only live if your blood is between pH ~7.35 and ~7.45. So even if you did succeed somehow in alkalinizing yourself, you would be dead.

WolverBean

August 8th, 2017 at 4:04 PM ^

"It was proven that cancer cannot thrive in an alkaline environment so intuitively it makes sense."

Cancer can't thrive in bleach or gasoline either, but that doesn't mean you should drink either of those (please don't!).

The pH inside your body is very, very tightly controlled. Your blood, for example, has a pH between 7.35 and 7.45, and if it deviates much from that window you get very sick very quickly (look up "acidosis" and "alkalosis" for more info). Meanwhile your stomach has a pH of about 1, which is acidic enough to cause chemical burns anywhere in your body other than in the stomach itself. These two facts alone should be enough to demonstrate that the pH inside your body is totally unrelated to the pH of whatever you eat or drink; otherwise our own digestive processes would kill us. (And if you take a bullet to the stomach this can be exactly what happens.)

I'm not a medical doctor, but I am the kind of doctor who can tell you that "electronically charged ionized water," while fancy-sounding, is a meaningless term. Baking soda is sodium bicarbonate. If you dissolve it in water, you will get a solution containing hydronium ions, bicarbonate ions, and a little bit of dissolved CO2. This solution is useful for scrubbing rust off pans, and if you add papier mache and vinegar, you can make a volcano with it; aside from that, there's nothing particularly magical about it. Or if your point was that you want a solution more alkaline than that, well, you can dissolve sodium hydroxide in water. This makes a better cleaning solution (look up "lye") but will also give you a chemical burn if you drink it or handle it without gloves. Either way, there is no basis for a belief that it cures cancer.

Nobody Likes a…

August 8th, 2017 at 9:25 AM ^

I have a good friend who is a rad onc at Davis and they do exceptionally good work. I tease her that she is doing a small part to repay osu’s karmic debt to the world. But it is good to know that someone as smart and dedicated as she is has chosen this to be her lifes work and that davis provides her with the chance to do it 

mo1997

August 7th, 2017 at 5:20 PM ^

Reprogramming a cell to grow into something else is the basis for most cancers. I wonder how they were able to control the growth? Then how did they turn off the mutagenesis? Did the cells continue to produce the new cell line or were they reprogrammed back? 1 set of genetic alterations is risky, 2 would increase the risk by multiples.

Still very cool though...I hope we can have nice things

Sopwith

August 7th, 2017 at 8:21 PM ^

I get a little giddy when my previous life as a biomedical researcher comes in handy on MGoBlog. Also, anything with wide receiver routes: theory and practice. But here, the former. I looked at the abstract of the published paper the article references and have a decent idea of how this works.

So, one useful thing is that what they're talking about here is a method for transfection of target cells with genetic material, which means adding exogenous genetic material (usually DNA, often in circular bits called "plasmids") through a cell's membrane where the protein(s) it encodes can be generated by the cell machinery without actually being incorporated into the chromosomes of the target cell. The DNA sequence can also act as a "promoter" of endogenous (host) genes to turn on beneficial proteins that are lacking in an injured or disease state.

When you actually change the target cell's genetic sequence by inserting directly into it's DNA (incorporating into the chromosome of the target), that's called cell transformation. In this case, you have some concerns about inserting into the wrong place and, e.g., deactivating a "tumor suppressor" (anti-cancer) gene or alternatively activating an "oncogene" (cancer promoting). Technology for targeting exactly where to insert the gene of interest has become much more sophisticated recently as some of you may have read (CRISPR-Cas9 is a technology which has revived the "designer baby" debate again, for example, because it makes transformation so much easier it seems to enable Huxley's Brave New World for realz this time).

But back to this story, transfection typically doesn't cause the permanent genetic change of a cell because as a cell divides, it tends to dilute the exogenous DNA that was added as further generations of the "daughter" cells emerge and the parent cells die off. Contrast with transformation, which tends to be permanent because the added gene replicates along with the transformed cell.

So the tl;dr version of the above is that while lab methods for similar treatments of cells with DNA segments have been around for decades, miniaturizing the process and making it essentially a little patchlike topical device to help deliver therapeutic genes through the skin right to the affected area (such as burns or other necrotic skin lesions) could take those lab techniques and make them far easier to apply in a clinical setting if they can make it consistent enough to pass the FDA's significant approval process.

That was so fun.

aratman

August 8th, 2017 at 10:47 AM ^

If they can turn on oncogene, can they program it to reproduce desired cells?  Like repairing a heart by having the body rapidly reproduce the cells that are defective?  This is getting to the crazy stage where it is happening so fast it is hard to predict what they will discover, hope science spending cuts don't impead the discoveries. 

Mgodiscgolfer

August 7th, 2017 at 11:22 PM ^

You might understand the help you knowingly or unknowingly give to people who have had multiple operations getting their bodies to function in one way or another. Living was never in doubt. mGrowOld comes along and puts perspective on any bone replacement, pins, even the losing of a limb you knew were going to live. Thanks mGrowOld keeping my perspective will be easier. The old saying "it can always be worse" so true.

Aged Wolverine 68

August 8th, 2017 at 11:21 AM ^

for 35 yrs now. It is too late in life for this to make much difference, but when they can magically heal things, it will help out future generations, and for that I am happy. Nasty disease.

MIMark

August 8th, 2017 at 11:21 AM ^

A good friend of mine died last year of leukemia or some similar type of cancer. He was an OSU alum and spent much of the last year of his life at the cancer center at the OSU hospital. Ultimately he died there, his condition was found too late. If the work and tests done in his time there lead to breakthroughs, my old friend in a way is able to live on.

He was a good man and a good friend.