The Colts are now 0-3, and most indications point to Peyton Manning not coming back until December, if he plays at all this season. The dorky guy in me who loves playing Madden Franchise mode when his wife will let him, loves this situation. Without Peyton, the Colts are an easy 3-4 win team if not less. Which creates an interesting situation come draft time with Andrew Luck being the odds on favorite to be the first over all pick. My feeling, is that as long as Peyton is still able to play, and can be effective, he's earned the benefit of the doubt. With that being said, this could be a great year for the Colts to trade down. With the new rookie cap in place, teams won't be nearly as cautious about trading up to the first pick. Plus, Andrew Luck is probably as can't miss as a QB will come. You could get a kings ransom for that pick, and if Peyton is healthy, that's definitely the way I'd go.
You really can't go wrong in this situation for the Colts in the draft, and that's rare in the NFL.