In the first eight games of MSU's schedule, there is only one team that they play which had a 2012 Sagarin number above 70.00, and that would be Notre Dame. Michigan State also plays five teams in their conference schedule whose rating was below the mean for the conference.
For comparison, we play three opponents with ratings above 70.00 in the first eight games, and only three opponents on the conference schedule with ratings below the conference mean for 2012.
Then again, if it is going to be an interesting journey just to get inside the 20 yard line, as it may be for State this year, I suppose you would want to do what State has done and open your conference schedule with the four worst defenses in the conference per last season's stats for total defense.
It will be interesting to see the Strength Of Schedule ratings come out around the end of July or so (I think that's when they start to appear anyway). As others have mentioned, between the schedule and this being the last year of this arrangement, it might be ages before they have another real opportunity.