The longer you play football the smaller your brain-memory-area

Submitted by ca_prophet on

The University of Tulsa and LIBR have published a study in the AMA Journal which studied 50 former/current Tulsa football players and shows that if you've suffered a concussion or played football for years (peewee, high school), the areas of your brain responsible for memory are statisically likely to be significantly smaller:

http://www.utulsa.edu/about-TU/news-events-publications/UniversityNews/2014/May/brain-study.aspx

Assuming that this data can be replicated, those of us who love college football could end up in the position of watching people slowly undergo long-term brain injury playing a sport we love to cheer for.  That's ... uncomfortable at the least.

 

 

Don

May 14th, 2014 at 4:48 AM ^

football will be played by bioengineered androids created specifically for the purpose. While that may seem depressing, the good news is that the Lions will finally win the Super Bowl in 2077 with an android replica of Barry Sanders.

XM - Mt 1822

May 14th, 2014 at 5:42 AM ^

where a few generations had to lose their parents to cancer (we did) before the connection is made between what someone does now, and what will happen to them in 30-50 years.   all 5 of my sons play or want to when they are old enough, and i played until i was 41 yrs old.  feel fine, no issues, but must admit i am thinking about it where before it would've never entered my mind. 

XM - Mt 1822

May 14th, 2014 at 10:18 AM ^

most of our starters had played pro or major college ball, as had the starters from the teams we played like NYPD, LAPD, LA Fire, Miami, Phoenix and others.   the games were played to raise money for various charities, many hundreds of thousands raised n that time.   we played all over the country and got to play in some very cool stadiums like the coliseum and jack murphy (now 'qualcomm').   the rest of the details are some decent stories over a beer, but i won't clutter up the blog with them.

this was all after hockey at mich.  incidentally, the only time i ever got knocked out was playing for the jr. wings against the windsor spitfires in the old windor arena.  diving/sliding to stop a guy's break away attempt back in the days when the nets were pegged into the ice with 10" pegs.   next thing i remember was waking up staring up at the lights, tucked way in the back of the net, with both coaches asking me if i was alright.  

XM - Mt 1822

May 14th, 2014 at 12:48 PM ^

that you get to play the game the longer you play.   i didn't contemplate that i would be playing football, much less in front of somewhere between 3K-20K people, on television, at that point in my life.  i was also the benefactor of an OC who was a wizard who had played QB at wyoming and was a champ.  i played TE/H-back and that was a feature position in his offense.   and as strange as it may sound to sane people, i love to run block probably as much as i like catching the ball. 

combine that with the comaraderie of playing with guys who you risk your lives for in your regular job, and short of the military it would be tougher to have a tighter bond with guys than that. 

BlueGoM

May 14th, 2014 at 6:30 AM ^

I had a concussion playing  in HS.  The more I read about the effects of concussions, the more I regret playing.   Combined with some sleep problems I (used) to have, I worry about my mental acuity later in life.

Ziff72

May 14th, 2014 at 7:10 AM ^

Is there any thought that maybe people who play football for a long time are people that are physically more gifted but maybe not as gifted mentally so in general the brain is not functioning at the highest level to begin with. What if they did a study that found that micro biologists tend to have muscular atrophy at a rate 20% higher than non micro biologists? Would that be because they are micro bioligists or because they are super smart nerds who don't ever leave a lab? Just a thought. I'd like to see what the brain of Junior Seau looked like when he was 10. My thinking is that a large group of men have played football since they were able to walk for a long time with no pads and no helmets in playgrounds up until high school with pads and helmets with no awareness of concussion problems. Wouldn't it stand to reason that if this concussion scare was as bad as they are saying that we would have an epidemic of guys walking into each other once they hit 50 for the last 60 years?

Mr Miggle

May 14th, 2014 at 8:05 AM ^

Your first sentence is incredibly ignorant on multiple levels.

You think that football players are idiots, that scientists have never heard of control groups and you ignored the differences between players who suffered concussions and those that didn't.  

BiSB

May 14th, 2014 at 9:44 AM ^

And it ignores the HUGE gap between "football players aren't smart" and "football players have significantly different brain structure than non-football players."

The former is insulting and inaccurate, but the latter is just... yeah.

1464

May 14th, 2014 at 8:06 AM ^

I'm usually one to point out false correlations, but in this case, I believe you are arguing against your stated point...

Not leaving the lab and being weak : Biology ::

Getting hit in the head a lot and losing memory : Football

You're arguing two distinct sides in the post above.

LSAClassOf2000

May 14th, 2014 at 9:03 AM ^

There is a lot that bothers me about what you said and how you said it because I feel it ignores some of the obvious problems which are now well-documented with regard to the risk the game of football carries for its players. That last thing you bring up does need some attention though, or so I believe.

The "concussion scare", as you call it, is not an imagined evil but a real phenomenon. The CDC, I believe, did an excellent cross-sectional study of over 3,000 former players who played at least five years in the NFL from 1959 to 1988 and found that the rate of diagnosable neurological problems (CTE, ALS and even Alzheimer's, among others - I think it focused mainly on recall and movement-related problems) was on average three times higher in the group of former NFL players than in the population at large. It wasn't a concrete neuroimaging study such as what they did at Tulsa, but you can't honestly say that it is merely a "scare". To me, that diminishes very real problems that these guys face as a result of their time in the league. 

MGoViso

May 14th, 2014 at 11:41 AM ^

LSA, honest question, and I hope it doesn't come off the wrong way. 

If you are convinced that it is not a scare but a very real problem (a premise I think represents your thoughts), what are your thoughts on the morality of supporting the enterprise as-is (via TV viewing, ticket purchases, much of MGoBlog, etc.)?

ca_prophet

May 14th, 2014 at 2:52 PM ^

... To me, this is the key question. How do you feel about watching and supporting college football in light of the increasing evidence that we're watching kids slowly lose their minds? Obviously that's a personal decision with factors from "they knew what they were doing" to "the raw numbers aren't bad" to "if I won't let my kid play, how can I watch this?".

jmdblue

May 14th, 2014 at 9:42 AM ^

but the point isn't "you can get hurt playing football".  The point is "you will very likely endure long term brain injury without necessarily knowing it if you play football for an extended period".  We've always known you might blow out a knee or suffer from arthritis due to football.  We even knew (God forbid) there was risk of paralysis.  No one knew there was a much-better-than-decent chance of becoming a 60 year old former boxer with 70 bouts under his belt. 

I watch my boy's practices and games very closely.  They just don't hit very hard at that age and there isn't enough volocityxmass out there to do much damage.  As he progresses, though, we'll have some frank discussions.

BiSB

May 14th, 2014 at 9:41 AM ^

There's a difference between "hurt" and "injured." If you're hurt, you can play. If you're injured, you should sit.

We're not talking about "hurt." We're talking about "injured" (and more specifically, "brain damaged")>

turd ferguson

May 14th, 2014 at 8:56 AM ^

I need to read this article later to see what it's really saying, but before people over-interpret the headline finding, note this paragraph from the summary:

"This research shows the correlation; the next step is to determine causation so that long-term brain injury can be identified and prevented," he said.

If this is really just a comparison between 25 Tulsa kids who played football and 25 Tulsa kids who didn't, without accounting for the loads of other likely differences between football and non-football players, then it might not be a very informative study. Not saying that it is or isn't, but I think that kind of thing always requires a careful read.

turd ferguson

May 14th, 2014 at 10:05 AM ^

Again, it could be a great study (annoyingly, I haven't looked at it myself), but even little issues and oversights can badly undermine a study's findings.
Truthfully, I find the problem much stronger on the other direction -- that so many people accept research results as truth uncritically. I think medical science is generally more trustworthy than social science, but that skepticism that surprises you seems very healthy to me.

BiSB

May 14th, 2014 at 10:22 AM ^

It's good to question studies, but it's really hard to look at these numbers:

Results  Players with and without a history of concussion had smaller hippocampal volumes relative to healthy control participants (with concussion: t48 = 7.58; P < .001; mean difference, 1788 μL; 95% CI, 1317-2258 μL; without concussion: t48 = 4.35; P  < .001, mean difference, 1027 μL; 95% CI, 556-1498 μL). Players with a history of concussion had smaller hippocampal volumes than players without concussion (t48 = 3.15; P < .001; mean difference, 761 μL; 95% CI, 280-1242 μL). In both athlete groups, there was a statistically significant inverse relationship between left hippocampal volume and number of years of football played (t46 = −3.62; P  < .001; coefficient = −43.54; 95% CI, −67.66 to −19.41). Behavioral testing demonstrated no differences between athletes with and without a concussion history on 5 cognitive measures but did show an inverse correlation between years of playing football and reaction time (ρ42 = −0.43; 95% CI, −0.46 to −0.40; P = .005).

And have your primary thought be, "well, maybe they just mathed wrong."

They used age-, sex-, and education-comparable individuals as a control group, and produced numbers that are (a) really, REALLY hard to explain away, and (b) are frightening as shit.

umumum

May 14th, 2014 at 10:30 AM ^

But this isn't the only study essentially reaching the same conclusion--by a long shot.  No one here is taking this one study as gospel, but rather as more cumulative evidence.

Healthy skepticism is fine, but your skepticism appears to be based more on your not liking the conclusion.  Please point us to contrary studies.

 

turd ferguson

May 14th, 2014 at 10:43 AM ^

Your second paragraph is stupid, since I have no agenda here, but I should just shut up, get to my laptop, and read the damn thing.
There's no doubt in my mind that they did the math right, BiSB (and those differences are huge). The math is the easy part. Getting the comparison groups truly comparable in a non-randomized controlled trial is the hard part. Throwing in a few control variables is far from a guarantee that you'll get remotely comparable groups in the ways that count.
I'm done talking out of my ass, though. It's probably a really good study. I just need to see for myself.

turd ferguson

May 14th, 2014 at 11:05 AM ^

That's not what I'm saying. And sorry to call your paragraph stupid -- it just felt like you were accusing me of something not close to true. If these guys had come up with the exact opposite result, I'd likely have urged the same caution. One more example of the challenge for non-RCTs here. Getting concussions in football is likely correlated with loads of other dangerous behaviors (as well as different body types, dispositions, etc.), even compared to other football players. I'm just guessing, but I could see the number of concussions guys get being correlated with things like recreational drug and alcohol use, steroid use, body size, time spent in other very physical sports, etc. The first thing I look for is whether I think the researchers did a reasonably good job of controlling for those types of differences. That's all I'm getting at, but I think it's the key question to what to think about any of these studies (or of the whole body of research, if no one seems to be doing this reasonably well).

gbdub

May 14th, 2014 at 10:30 AM ^

It's not indicting the thoughtfulness of the researchers to note that the study was limited in scope, limiting the broad conclusions that can be reasonably drawn. Even the researchers would acknowledge that - given unlimited time and funding I'm sure they would have done much more.

First, 25 samples at one school is hardly a representative sample, nor is it large enough to offset a ton of internal variation. D1 athletes are not representative of the football playing population at large (nor are D1 students) even at a "mid-major" like Tulsa.

Second, this study was a snapshot - what did these brains look like 5 years ago? 10? When did the damage occur? Or we're the brains always different?

Another interesting group would have been "students who had been diagnosed with a concussion from something other than football".

BiSB

May 14th, 2014 at 10:36 AM ^

"25 samples at one school is hardly a representative sample nor is it large enough to offset a ton of internal variation"

I think you mean it isn't a sufficiently sized sample, though it seems like a pretty good size number to me. But look at those P-numbers. There is a chance, mathematically, that these variations arose by chance... but that chance is like win-the-lotto-sized. Even the best-case scenario side of the 95% confidence interval is well within the "yeah, there's a problem" range.

gbdub

May 14th, 2014 at 11:44 AM ^

P values still have a lot of assumptions built in. In this case your null hypothesis is something like "average hippocampal volume is equal in both football players and non football players". But in calculating the p value, they still have to assume their sample is an unbiased selection from whatever population they are applying it to (All football players? D1 football players? Tulsa football players? Did they run it as single tailed or two tailed?).

And while a statistically significant difference in hippocampal volume is supported by this study, is that a medically significant amount (I assume it is, but I'm not a neuroscientist)? What does it translate to medically?

In any case, as the authors note, this is just a correlation study. There's still a lot of work to do to figure out exactly what's causing this, if we hope to come up with useful solutions (other than "never play football").

I don't think anyone is saying that this study isn't important or was poorly operated. Certainly no one ought to claim that science supports the idea that football is harmless to the brain. It's just that, as usual, headlines get ahead of the science and get used as bludgeons for people to sell papers and support their pre-existing conclusions.

youn2948

May 14th, 2014 at 2:00 PM ^

Would be a long term study of students who did didn't play, the size and development, before and after etc. Could size be determined by activity upon puberty etc.

*shrug*  Yes concussions screw your brain, how badly, what's the rate and what can we do?  More people go to the NFL and limited to 10 years pro etc?  10 concussions and too bad?

Anywho.  25 is still a small sample size even if you're calling it 75 total, but all research put together can slowly draw a big picture and/or setup better future studies.

maizenbluenc

May 14th, 2014 at 10:24 AM ^

25 kids who play baseball, and 25 kids who play soccer, and 25 kids who play hockey, 25 kids who play lacrosse, and 25 gymnasts, and 25 kids who longboard with no helmet, etc.

It seems like all these studies focus on football, and head trauma is common in other sports as well.

This is all about choice. If someone chooses to longboard without a helmet, they are responsible for the risk of brain trauma from an accident. (My son and I argue all the time about wearing a buckled helmet / "but dad many guys don't: it's not cool".)

The point is these people are gifted at something, and love doing it despite the risk, AND many pursuits hold a risk of brain trauma. Should the risks be reduced through rule, care, and technique changes, and better protective technology? Yes.

Ah heck, I guess we all should not leave our houses and get our sports fixes from nice safe video games instead .... we're certain to have a longer lifespan that way /s

M-Dog

May 14th, 2014 at 9:13 AM ^

For safety reasons, the game is much different than it was 100 years ago.  And for the same reasons it will be much different 100 years from now.

We may lament losing some cool aspects of the game, but we survived losing the very cool flying wedge OK.  

 

CRISPed in the DIAG

May 14th, 2014 at 9:26 AM ^

This is an honest question because I didn't play past high school, but how hard is it to actually avoid helmet-to-helmet contact?  Ex players on ESPN are the first to complain about the practical enforcement of this rule.  It seems entirely logical to me: don't hit players in the head.  Again, I don't know...is is this possible given the speed and size of *today's* players.

BiSB

May 14th, 2014 at 9:47 AM ^

You really can't. How are two linemen supposed to avoid jarring blows to the head?

You can (and should) teach heads-up techniques that reduce the risks of neck injury and limit the incidence of spearing, but a perfect form tackle still jars the brain against the skull with great force.