DISCLAIMER:This is meant to be an **objective** analysis of how David Brandon's other political aspirations mean for his AD candidacy. It is simply meant to provide context to the discussion of his potential hiring, and nothing else. I am NOT trying to start a political debate.
Brandon's window to join the 2010 gubernatorial election is basically closed, and it is extremely unlikely that he would run. The basic reality is that the GOP field (in which Brandon would participate) is basically already full of three, "top-tier" candidates who've already laid the groundwork for campaigns, begun to seal up endorsements, hire consultants, and soforth. It'd be extremely unlikely (not to mention pretty foolish) for Brandon to run in 2010.
As for the future, that's a different story. The guy lives in a congressional district where he's unlikely to ever win as a Republican unless he relocates, but the guy's always had statewide aspirations anyway. The smart money right now is on a Republican to win the governorship in 2010 -- that means Brandon would be unlikely to run until 2018 (assuming the GOP incumbent seeks a second term; at earliest, Brandon would be angling for 2014).
Sen. Stabenow is viewed as a potentially more vulnerable Democrat, relative to Sen. Levin at least, and she's up for reelection in 2012. This would by far be the most tempting and most likely race for Brandon to enter in the immediate future, and I would imagine he would be atop of the national GOP's recruitment list. Races of that sort usually need about a two-year lead time to be run properly, meaning that if Brandon were to assume the AD position in late 2010, he'd effectively be leaving the job as soon as he started. Levin is set to face reelection in 2014, however, at which point he'd be 80 years old. That puts Levin in retirement range, but it's no guarantee for a vet like him, and certainly not without precedent in the Senate for an octogenarian to seek reelction.
In short: For David Brandon to become AD, he would need to wave off a challenge to Stabenow in 2012 to probably satisfy U-M. If we want him to be seriously paying attention to his job for more than two years, it would likely require a commitment for him to wave off any 2014 gubernatorial or Senate races. The guy's youth is probably an asset in a race now; down the line, he'd be a little older of a candidate should he forfeit opportunities for the Michigan AD job. It would seem he'd have to forsake a lot of political aspirations to take the job.