Football Display Case
I don't think they changed Les at all actually
national champs baby
Patrick Hruby is doing God's work.
first comment: "EVERY ATHLETE HAS ASPIRATIONS OF WINNING AND WE HAVE OUR FAVORITES BUT IT IS ALWAYS A PLEASURE TO OTHER STUDENTS ACHIEVE THEIR GOALS, TOO!"
stupid Pistons and their refusal to tank properly
rundown of Michigan's riser
needs moar usage
so much for that
This list is completely arbitrary and not a genuine analysis of the relative merits of state fossils.
will be michigan's highest pick in a while
money has to go somewhere
I am only motivated by people who have no opinion about me.
the just released schedules were a flat-out statement that the B10 doesn't believe SOS will matter in playoff selection
but I thought that draft was supposed to be incredibly loaded?
Report by CBS Sports:
The deer antler spray and other nonsense are banned substances, and were given out for free. As the article notes, this will amount to nothing.
What the hell is deer antler spray?
Ask Ray Lewis
If I tell you it's Easter, you better start looking for eggs.
Some folks call it a sling blade, I call it a kaiser blade.
this may be the funniest pic I've ever seen on here.
Full disclosure: this is not my work. I did a Google search.
Weird that that picture already existed.
Ray Lewis was accused of using deer antler spray first. The Bama connection came later in the day, when they realized the same company had dealings with them
Oh, OK. Not so weird then, you're right.
No it's not. It's the internet. What's weird is that deer antler spray hasn't been Rule 34'd yet.
"I recently heard from fans and friends that Michigan will be great again one day. In my opinion, Michigan never stopped being great." --Zac Ciullo
You must have done a very thorough and exhaustive search. I would highly recommend cleaning your browser history.
What about deer antler roll-on?? Can I still use that?
must... resist... urge... to google search deer antler spray porn
I think I just pissed myself
Can't stop laughing.
"You know, for a bartender/bookie, you're pretty judgmental."
Ask and ye shall receive!!
"What do people mean when they say the computer went down on them? " -Marilyn Pittman
Extract of Deer antler, has natural growth hormone in it. yummy.
Is that what they do in the south?
"There will be blood on the field and it won't be mine." -KK
with deer in the south... Or swine for that matter. Now squeal like a pig Saban.
I just don't care anymore.
I mean, when you're already winning tainted championships, you might as well do everything you can to make sure you actually win them.
"We've beaten Michigan the last four years. So where's the threat?"
- Mark Dantonio
Blogging the Virginia Cavaliers at http://fromoldvirginia.blogspot.com/<
and it does not work. Why this is banned is beyond me.
"Deserve to Win!"
What is it supposed to do?
It's got a variant of HGH in it
It's got electrolytes
It's what plants crave
How many times have you been on the freeway and had someone fly by you at 100 mph then end up 2 cars ahead of you at the off ramp? What's the point? -Mark Harmon
I've never seen no plants grow out of no toilet.
Intensity is a lot of guys that run fast.
Some does. There is a lot of different brands and companies that distribute it. I would assume the pros use top of the line sprays. It's rediculous that its a banned substance anyway. It helps you heal from injuries and has no known bad side-effects.
"im saying to myself should i do it should i not. I crossed the goaline and hey...fuck it" Desmond Howard on his Heisman pose
Form of Growth Hormone, From http://www.deerantlerspray.org/
Red Deer Antler Velvet is something that Asian medicine has known about for a very long time, well over 2000 years, but only lately has the Western world caught on to. Taken from mature male Red Deer, this substance is processed and used in both traditional Chinese medicine and in Western culture as a nutritional supplement. In the west it is called “deer antler spray” or deer antler velvet. No matter what the name, it is harvested from populations of Red Deer in New Zealand. These farmed deer are known to be disease free and thus provide the best quality antler velvet.
Although it has been known to work for centuries, although only in the last thirty years has science uncovered why. The active ingredient in this product is a very effective growth hormone that has great impact on the human body. While it can be taken in a powdered form, via pill or in a drink, the most popular form is in a spray. This spray is known as red deer antler spray and has a fat based delivery system that claims to deliver the hormone into the bloodstream faster and have more of the hormone where it will do the most good for longer then a pill or powder can.
This is a product made from Red Deer farmed in New Zealand. Male Red Deer produce antlers each year, and these antlers are removed from the animal while they are still “velvet” covered to keep the males from injuring each other. This material can be taken from the deer just like a fingernail can be removed by certificated farmers and Veterinarians, leaving the animal unharmed. Because antlers grow at an astounding speed, the entire harvest takes just a few weeks. After removal the velvet deer antler is freeze dried and processed into various forms from powders and pills to sprays.
Deer antler spray has been linked to a number of hormones that are proven to have positive health benefits. The most important is IGF-1. IGF-1, or Insulin-like Growth Factor-1, is the star hormone here. This performance enhancing chemical is naturally made by the body, and thus is hard to detect in standard dope-testing. It is a byproduct of HGH in the body. And where HGH is heavily controlled, getting IGF-1 into the blood through the use of these sprays is legal. It has been proven that IGF-1 helps with muscle development and performance. It does this by transporting energy and building blocks that muscles need. More being delivered to the muscle cells mean they can work faster at healing or growing.
The side effect of this is that by using deer antler spray one can improve athletic performance, simulate the metabolism, improve the overall condition of the heart, and help fight off colds and flu. By allowing the body to burn off more stored sugars and require the burning of fat stores to fuel increased muscle use, this spray can do a lot in way of rejuvenation on the body. This may help with nerve damage repair as well. Deer Antler spray has IGF II, NGF, TGF-B, EGF, FGF, and a score of other growth factors, in addition to a wide range of proteins as well.
This is a very popular nutritional supplement. It is also nearly impossible to detect if it is being used. This is one reason why such sport figures like Bengals safety Roy Williams feel as though they can come right out and admit using deer antler spray on a regular basis. Mr. Williams has never come up positive on a doping test, so even though IGF-1 is a banned substance in the NFL, there is no way that a urine- based test can detect it. Coaches (like Hue Jackson), athletes (yep even the legendary Ray Lewis), who knows who else, all use this spray, and for all we know, really, there’s little harm in it.
Fact is, deer antler spray is based in medicine used in Asia for centuries. The spray is natural, discrete, effective, and for the most part clean to use. Since it is something that naturally occurs in the body it cannot be detected by standard tests. There appears to be limited long term risks involved in using it, although there are some well documented benefits to it. While it might not be for everyone, deer antler spray does have positive points for those who do need it, and increasingly many people will find they do need it.
Peer reviewed references or it didn't happen?
Tenim un nom el sap tothom. Barca, Barca, BAAARCA!
Thanks for that.
Has it been proven to work in the form of deer antler spray?(can it be absorbed and utilized through the skin? Through the Gi tract?) or would it need to be injected to the bloodstream to have an actual effect?
Sublingually is the preferred administration..
I made the mistake of clicking on that link. Is that in English? I feel small and dumb. I have both an engineering (from UM) and a law degree, and I felt insignificant and unworthy to read that medical-science stuff. Wow.
Can someone translate it? What's it mean?
They very thoroughly explained that muscle tissue, in the presence of IgF-1 will gain mass, or at least not atrophy due to age.
If it makes you feel any better, (we) medical folk who are fluent in that type of writing usually can't make heads or tails of engineering schematics or legal documents.
That paper's abstract boils down to "Muscles have a natural, pre-programmed way to regenerate. This can be exploited and used to make muscles grow extra big if the muscles are exposed to IGF-1. Blah blah blah we're really important because we proved this, here's our paper, now give us some sort of award."
Michigan: 903–315–36 (Best in NCAA)
vs Ohio State: 58-44-6
vs Notre Dame: 23-16-1
vs MSU: 68-32-5
vs B1G: 522-197-24
vs SEC: 20-8-1
vs PAC 12: 48-24-1
vs Big 12: 10-5-1<
would eventually allow me to shine on an internet message board someday. That day has arrived.
It's just an abstract and not a full paper, so there's not much to it other than to say that the lab added the gene for IGF protein to skeletal muscle cells and then measured those cells for growth activity using a standard method (it's indirect-- they look for activity at a "transcription factor" called GATA-2 which ordinarily won't get turned from DNA into RNA, so when they see lots of it, they know the muscle cell is turned on).
So "localized IGF transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle" is just a way of saying "we made IGF just in this one type of non-growing muscle cell and voila, it started getting pumped up like Popeye eating spinach."
Given that they noted using "transgenic embryos," it's a good bet this was done in mice. Yes, you probably guessed what that means. Mice are now strong enough to take over the world.
I for one welcome our new murine overlords.
I only have my Bs in biology so my experience with research is limited... What are your experiences with transgenic vs just adding the substance? Ie. if the researchers in the study above had added IgF-1 rather than having it expressed as a gene, would the results have been different?
Edit- biology, not bology. Autocorrect never works when u wish it would.
that IGF-1 or HGH or other substances will increase lean muscle. Your point about bioavailability is spot on. The amount of the hormone and it's method of administration (and absorption) is what matters.
Ok so will the spray work??
Serious question because i was planning on starting to weight train again. I'd buy some of this if I knew it was real but this just sounds like a 2010's version of snake oil.
Because I don't give a shit?
1. How much IGF1 is in what you are buying. These kind of products generally don't have great quality control and are mostly "fillers" (inert substances).
2. How will the drug be applied. A spray could work if formulated correctly to penetrate the superficial tissues (epidermis and dermis) but would have a mostly local effect on the underlying skeletal muscle. A cream or ointment would probably work better because of increased contact time. An oral formulation could also work but you'd need a bigger concentration and have to worry about first pass metabolism.
So, yeah, it could work but only if formulated and applied correctly and used in conjunction with a strength training program.
Most likely, simple exogenous (i.e., free-form protein just kinda dumped on the cells) addition of IGF-1 would give you some measurable effect on a simple in vitro cell-culture assay, assuming the muscle cells have a surface receptor for the stuff.
But in the mouse model they're using in the paper, you can't really pump IGF into the mouse for that long, and even if you did, you could get effects all over the organism depending on bioavailability, not just the muscle. What they did was much cleaner and fancy: put the gene for the expression into the embryo under the control of a muscle cell promoter, so it only turns on in muscle cells and you can isolate the effect. That's more of a gold-standard approach; the quick-and-dirty proof-of-concept would be what you describe, just feeding the stuff to the cells.
Was going to respond but I couldn't have explained it better.
I did a lot of research in on skeletal muscle during undergrad. If your'e curious, Ron Allen at Arizona has done quite a bit of work on the effects of growth factors on skeletal muscle growth and development. Here are two more relevant abstracts:
Apparently one side effect is an inability to edit your own writing.
"Mattison must break you. Jake Ryan is his tool."
I don't even know where to begin. Despite the lousy writing that might suggest otherwise, I can assure you a scientist did not write this.
What the fudge does "certificated farmer' mean, anyway?
Right, they just let anyone publish in Nature Genetics I think.
Different types of science have different communication standards. In a journal like Nature Genetics, an author isn't writing to their mom, they are writing to another top expert in their own field. What pray tell makes you think a scientist didn't write this?
Edit, nevermind, you replied to the weird website copy/paste post. Carry on.
Are you a park ranger at Yellowstone? Say hi to Yogi Bear for me. - the_big_house 500th
I may not be a 70 year old man. - Herm
You think "deerantlerspray.org" is run by the journal Nature Genetics?
The Nature group of journals are some of the highest impact-factor journals in the world. See that abstract cited a few posts down? (or up, depending on your settings) Read that abstract. That's written by a qualified scientist in a Nature journal.
How about the most painfully obvious stupidity in the whole thing-- that deer antler spray "can't be detected" because it is naturally occuring in the body. In whose body? Deer? If you have a non-human protein floating around in a human, it's not that hard to detect it, assuming the excretory or immune system hasn't cleared it already as a protein from a foreign animal that is not known for homogeneity to humans and wouldn't have a cognate cellular receptor in a human, much less one localized to myocytes (muscle cells).
Oh, my head.
Yes, I saw the link to Nature Genetics and I thought you were replying to that post. My bad for getting confused as to what post you replied to. Chill out and enjoy this kitten fight.