Denard is a transcendent talent. He has the ability to thrive in virtually any offense.
Hoke is getting a bit of a raw deal here, because if you watch video of his offenses at SDSU and Ball State, you'll see that Hoke likes to use multiple sets. His offense is different from Carr's, as Hoke does open things up a bit more, by spreading the field and utilizing roll outs.
Nate Davis ran for over 300 yards his junior (and final) year at Ball State, and he was not someone you would describe as a mobile QB. So the opportunities are there for the run, granted there are only going to be a tiny fraction of the designed run plays that Rich Rod's read option offered.
Mike Vick didn't run a read option offense and was as dangerous a runner at the quarterback position as anyone in the history of college football. IMO Denard is every bit as explosive running the football as Vick (probably more), and while he doesn't have Vick's arm, Nard Dawg's passing stats from this past season easily beat anything Vick ever did at Va Tech.
While the read-option probably fits Denard best, I don't think it's wise to make the assumption that Denard won't produce at a high level in another style of offense. I'm sure Hoke will tailor his packages to fit Denard's skill set.